Preheat oven to 350°F. Set the pie crust on a rimmed baking sheet.
Lightly crush the pretzels and roughly chop the pecans.
Combine pecans, coconut, chocolate chips, butterscotch chips, toffee bits, pretzels, graham crumbs, and salt in a bowl.
Spread the mixture evenly into the pie crust and level the top.
Whisk condensed milk with vanilla and brown sugar until smooth and pourable.
Drizzle the condensed milk mixture over the filling. Gently press to compact.
Shield the crust edge with foil to prevent over-browning.
Bake 35–40 minutes until the center bubbles and the top is golden. Rotate once midway.
Cool completely on a rack, at least 2 hours. Chill 30 minutes for neater slices before serving.