Preheat Oven: Preheat your oven to 375°F (190°C). Lightly grease a 9x13-inch baking dish.

Cook Pasta: Cook the ziti pasta according to the package instructions until al dente. Drain and set aside.

Prepare the Sauce: In a large bowl, mix the marinara sauce, Alfredo sauce, Italian seasoning, and red pepper flakes (if using).

Combine Cheese Mixture: In a separate bowl, mix the ricotta cheese, mozzarella, Parmesan, Romano, and Asiago cheeses until well blended.

Assemble the Dish: Add the cooked pasta to the sauce mixture and toss until coated. Layer half of the pasta mixture in the prepared baking dish. Spread the cheese mixture evenly over the pasta, then top with the remaining pasta mixture.

Prepare the Topping: In a small bowl, mix the breadcrumbs with the melted butter. Sprinkle the mozzarella cheese over the pasta, followed by the breadcrumb mixture.

Bake: Bake in the preheated oven for 25-30 minutes, or until the topping is golden brown and the cheese is bubbly.

Serve: Remove from the oven and let rest for 5 minutes before serving. Garnish with fresh parsley, if desired.