Whisk flour, yeast, salt, sugar, Italian seasoning, garlic powder, and red pepper flakes in a large bowl.
Pour in water and 1 tablespoon olive oil. Stir with a spoon until a shaggy, sticky dough forms.
Cover the bowl tightly and let the dough rise at room temperature for 12–14 hours until bubbly and doubled.
Oil a 9x5-inch loaf pan with the remaining olive oil and dust the bottom with cornmeal.
Scrape the dough onto a lightly floured surface. Gently fold in half the mozzarella and half the pepperoni.
Shape into a loaf with a taut surface and place seam-side down in the prepared pan.
Cover and let rise until puffy, 30–45 minutes. Meanwhile, preheat the oven to 425°F.
Spoon the pizza sauce over the top. Add remaining mozzarella and pepperoni, then sprinkle Parmesan.
Bake 35 minutes until deeply golden and the center registers about 200°F. Cool 10 minutes.
Loosen the edges, lift out, and garnish with basil. Slice and serve warm.
Notes
Try swapping pepperoni for cooked sausage or diced bell peppers. For crispier edges, bake on the lower oven rack. Store leftovers airtight for 2 days or freeze slices up to 2 months; reheat in a 350°F oven until warm.This recipe is an original creation inspired by classic No-Knead Pizza Bread Recipe flavors. All ingredient ratios and instructions are independently developed.