Preheat the oven to 375°F and position a rack in the center. Lightly grease a 1½-quart baking dish or 9-inch oven-safe skillet.
Cook the bacon in a skillet over medium heat until crisp. Transfer to paper towels to drain, then crumble. Pour off all but 1 tablespoon of the bacon drippings.
Add the chopped jalapeños to the skillet with the reserved drippings and sauté 2 to 3 minutes to soften slightly; set aside to cool for a few minutes.
In a medium bowl, stir together the panko, melted butter, and Parmesan until evenly coated. Toast this mixture in a dry skillet over medium heat for 2 minutes, stirring often, just until lightly golden. Let cool.
In a large mixing bowl, beat the softened cream cheese with a hand mixer until fluffy, about 1 minute. Mix in the sour cream, garlic powder, onion powder, smoked paprika, and lime zest until smooth.
Fold in the sautéed jalapeños, half of the crumbled bacon, and half of the green onions. Add the shredded Mexican blend, reserving 1/4 cup for topping, and fold to combine.
Spread the mixture into the prepared baking dish. Sprinkle the reserved 1/4 cup shredded cheese over the surface, then cover evenly with the toasted panko-Parmesan topping, pressing lightly to help it adhere.
Bake for 18 to 22 minutes, until bubbling at the edges. For a deeper golden crust, broil for 1 to 2 minutes, watching closely.
Let the dip rest 5 minutes. Finish with the remaining bacon and green onions. Serve hot with tortilla chips, crackers, or crisp veggies.