Heat the oven to 375°F. Lightly grease a 1.5- to 2-quart baking dish.
Cook the bacon in a skillet over medium heat until crisp. Transfer to a paper towel–lined plate and chop; reserve about 1 tablespoon of bacon drippings in the skillet.
Add the chopped jalapeños to the skillet with the reserved drippings and cook 2–3 minutes, just until slightly softened; set aside to cool for a few minutes.
Stir together the panko, Parmesan, and melted butter in a small bowl until the crumbs are evenly moistened; set aside.
In a large bowl, beat the softened cream cheese with a hand mixer until smooth and fluffy, about 1 minute. Mix in the sour cream, lime juice, garlic powder, onion powder, cumin, smoked paprika, and a pinch of salt and pepper.
Fold in the cooked jalapeños, 8 oz of the shredded cheese, and 2/3 of the chopped bacon until evenly distributed.
Spread the mixture into the prepared dish. Sprinkle the remaining 2 oz (about 1/2 cup) cheese in an even layer over the surface, then cover with the buttery panko mixture. Scatter the remaining bacon on top.
Bake 18–22 minutes, until the edges are bubbling and the topping is deep golden. For extra crunch, broil for 30–60 seconds, watching closely.
Let the dip rest for 5 minutes before serving. Serve warm with tortilla chips, crostini, or fresh veggie sticks.