Preheat smoker to 225°F with indirect heat. Use a mild wood like apple or cherry.
Melt the butter. Whisk in Worcestershire and hot pepper sauce until smooth.
Stir together garlic powder, onion powder, smoked paprika, ranch mix, brown sugar, cayenne, salt, and pepper.
Add crackers to a large bowl. Drizzle with the butter mixture and toss to coat evenly.
Sprinkle the seasoning blend over the crackers. Toss gently until every piece looks seasoned.
Spread crackers in a single layer on a mesh grill pan or perforated sheet.
Smoke for 60 minutes, stirring every 15–20 minutes, until dry, lightly toasted, and fragrant.
Cool on the pan for 15 minutes to crisp. Serve or store airtight.