Slice chicken into even strips and pat dry with paper towels.
Whisk buttermilk and hot sauce in a bowl. Add chicken and toss to coat; set aside while you prep.
Stir flour, cornstarch, 0.75 tsp salt, black pepper, garlic powder, smoked paprika, onion powder, and cayenne in a shallow dish.
Combine panko, Parmesan, and remaining 0.75 tsp salt in a second shallow dish.
Heat oil in a large skillet to 350°F over medium heat.
Lift chicken from buttermilk, let excess drip, coat in flour mixture, then press into panko to adhere.
Fry in batches 3–4 minutes per side until deep golden and 165°F inside. Do not overcrowd.
Drain on a rack or paper towels and season lightly with salt if needed. Serve warm with your favorite dip.