Heat oven to 350°F. Line two baking sheets with parchment.
Blend the sausage and softened cream cheese in a large bowl until evenly combined.
Add baking mix, cheddar, garlic powder, onion powder, paprika, and pepper. Drizzle in the milk and mix until the dough holds together.
Scoop tablespoon portions and roll into balls. Arrange 1 inch apart on the prepared sheets.
Bake until golden and cooked through, about 22 minutes. Rotate pans once for even browning.
Rest 5 minutes on the sheet, then serve warm.