Preheat oven to 350°F. Line a sheet pan and set a large sheet of foil on it.
Score the loaf in a 1-inch crosshatch, cutting almost to the bottom but not through.
Melt the butter, then stir in garlic, rosemary, thyme, orange zest, honey, salt, and pepper.
Slice the brie into thin pieces or small wedges.
Tuck brie into the cuts of the bread. Spoon cranberry sauce into the gaps around the cheese.
Drizzle the herb butter over the loaf, letting it seep between the slices.
Wrap the bread loosely in foil and bake for 15 minutes.
Open the foil and bake until the cheese melts and edges crisp, 10 to 12 minutes more.
Rest 5 minutes. Scatter toasted pecans on top and serve warm.