Preheat the oven to 475°F with a 12-inch cast-iron skillet on the center rack.
Warm 1 tbsp olive oil in a large pan. Brown the beef and onion for 5–6 minutes; drain excess fat.
Stir in garlic and cook 30 seconds. Season with salt and pepper.
Fold in ketchup, mustard, Worcestershire, and relish. Simmer 2–3 minutes to thicken, then remove from heat.
Dust the counter with flour and stretch the dough into a 12-inch round.
Carefully remove the hot skillet. Add the remaining 1 tbsp oil and swirl to coat. Sprinkle sesame seeds around the pan’s edge.
Lay the dough into the skillet and gently press it up the sides.
Scatter half the cheddar and mozzarella over the dough. Spoon the beef mixture evenly on top, then add the remaining cheese.
Bake 12–14 minutes until the crust is deep golden and the cheese is bubbling.
Whisk mayonnaise with 1 tsp ketchup, 1 tsp mustard, and pickle brine. Add crushed red pepper if you like heat.
Rest the pizza 5 minutes. Top with pickle chips, tomatoes, and lettuce. Drizzle the sauce, slice, and serve.
Notes
Try adding crisp bacon or swapping cheddar for American for extra cheeseburger vibes. Leftovers keep in the fridge up to 3 days; reheat in a hot skillet to revive the crust.This recipe is an original creation inspired by classic Cheeseburger Skillet Pizza Recipe flavors. All ingredient ratios and instructions are independently developed.